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Use of medicines for COVID-19 during pregnancy is higher in patients with more severe disease, according to a study. In addition, a trend towards increased corticosteroids use has been observed and appears to be consistent with changing guidelines.

COVID-19 medicine use in pregnancy increases with disease severity

19 Apr 2023

Advanced disease, recurrence precede brain metastasis from gynaecologic cancers

Patients with brain metastasis from gynaecologic cancers often present with an advanced stage disease and have had at least one prior recurrence, according to a study. In addition, the presence of an extracranial disease is common at the time of brain metastasis diagnosis.

Advanced disease, recurrence precede brain metastasis from gynaecologic cancers

Maximal transurethral resection tied to better outcomes at cystectomy

Pathological response at cystectomy may improve with maximal resection in patients undergoing transurethral resection for muscle-invasive bladder cancer prior to neoadjuvant chemotherapy, according to a study.

Maximal transurethral resection tied to better outcomes at cystectomy

19 Apr 2023

Higher sodium intake tied to higher atherosclerotic burden

Increased sodium intake is associated with increased coronary and carotid atherosclerosis burden in the general Swedish population, even in normotensive individuals and those without known cardiovascular disease (CVD), the SCAPIS* study finds.

Higher sodium intake tied to higher atherosclerotic burden

19 Apr 2023

Naltrexone of little help in reducing arthritis-related pain

Treatment with low-dose naltrexone does not appear to reduce nociceptive pain among patients with arthritis, as reported in a small pilot study.

Naltrexone of little help in reducing arthritis-related pain

19 Apr 2023

Add-on dostarlimab boosts PFS in endometrial cancer

Adding dostarlimab, an immune checkpoint inhibitor, to standard-of-care chemotherapy significantly improves progression-free survival (PFS) in patients with primary advanced or recurrent endometrial cancer, including those with dMMR-MSI-H* disease, according to the first interim analysis of the ENGOT-EN6-NSGO/GOG-3031/RUBY trial presented at SGO 2023.

Add-on dostarlimab boosts PFS in endometrial cancer

Over-the-scope clips more effective than standard treatment for nonvariceal upper GI bleeding

A randomized controlled trial of 190 patients from university teaching hospitals in Hong Kong, mainland China, and Australia finds that initial treatment of nonvariceal upper gastrointestinal (GI) bleeding with over-the-scope clips (OTSCs) reduces the risk of further bleeding vs standard endoscopic haemostatic treatment.

Over-the-scope clips more effective than standard treatment for nonvariceal upper GI bleeding

Unhealthy lifestyle habits up risk of idiopathic pulmonary fibrosis

An “unfavourable” lifestyle appears to put individuals at increased risk of developing idiopathic pulmonary fibrosis, especially those with high genetic risk, according to a study.

Unhealthy lifestyle habits up risk of idiopathic pulmonary fibrosis

18 Apr 2023

Biofeedback-virtual reality device beneficial in chronic migraine

For individuals with chronic migraine, frequent use of a portable biofeedback-virtual reality device leads to a decreased frequency of acute analgesic drug use and an improvement in depression, as shown in a pilot study.

Biofeedback-virtual reality device beneficial in chronic migraine

18 Apr 2023

Add-on alirocumab reduces coronary plaque burden in patients with familial hypercholesterolemia

In the treatment of patients with familial hypercholesterolemia, adding alirocumab to high-intensity statin therapy leads to a significant reduction in plaque burden and plaque stabilization, according to data from the ARCHITECT* study.

Add-on alirocumab reduces coronary plaque burden in patients with familial hypercholesterolemia