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Treatment with intravenous ertapenem yields improvements in the clinical and inflammatory markers of hidradenitis suppurativa (HS), according to a retrospective study.

Ertapenem infusion beneficial in hidradenitis suppurativa

LDL-C–lowering therapies bear a small risk of haemorrhagic stroke

24 Feb 2024 bởi

Medications that regulate low‐density lipoprotein‐cholesterol (LDL‐C) levels appear to contribute to a slight increase in the risk of haemorrhagic stroke events, according to a meta-analysis.

LDL-C–lowering therapies bear a small risk of haemorrhagic stroke

Pembrolizumab delivers long-term survival benefits in advanced esophageal cancer

24 Feb 2024 bởi

First-line pembrolizumab (pembro) plus chemotherapy (chemo) in patients with untreated advanced esophageal cancer demonstrates robust efficacy after 5 years, with no new safety concerns, when compared with placebo plus chemo, according to a study presented at ASCO GI 2024.

Pembrolizumab delivers long-term survival benefits in advanced esophageal cancer

Methylnaltrexone proves safety in paediatric oncology patients with constipation

Subcutaneous methylnaltrexone is safe to use in children with cancer who have opioid-induced constipation, suggest the results of a study. In addition, this agent stimulates bowel movements in more than a third of paediatric patients.

Methylnaltrexone proves safety in paediatric oncology patients with constipation

24 Feb 2024

Abatacept may mitigate rheumatoid arthritis development in at-risk individuals

24 Feb 2024 bởi

The use of abatacept in adults at high risk of rheumatoid arthritis helps protect against disease onset, as shown in the phase IIB APIPPRA study.

Abatacept may mitigate rheumatoid arthritis development in at-risk individuals

24 Feb 2024

Patients on anticancer therapeutic agents may develop carpal tunnel syndrome

Carpal tunnel syndrome (CTS) is not uncommon in patients being treated with anticancer therapeutic agents, reports a study. Electrodiagnostic (EDX) studies and ultrasound (US) are necessary in the diagnostic assessment of these individuals.

Patients on anticancer therapeutic agents may develop carpal tunnel syndrome

Low-dose oral midazolam not linked to improved patient satisfaction after surgery

Premedication with low-dose oral midazolam in older patients undergoing a surgical procedure falls short of improving perioperative patient satisfaction, according to a study.

Low-dose oral midazolam not linked to improved patient satisfaction after surgery

Acetylcholinesterase inhibitors may have potential protective effect against AMD

In the treatment of individuals with Alzheimer’s disease, acetylcholinesterase inhibitors (AChEIs) appear to confer a small reduction in the risk of age-related macular degeneration (AMD), as shown in a study.

Acetylcholinesterase inhibitors may have potential protective effect against AMD

TRT boosts sexual function, eases symptoms in men with hypogonadism

Testosterone replacement therapy (TRT) can help increase sexual activity, improve hypogonadal symptoms, and boost sexual desire among middle-aged and older men with hypogonadism and low libido, reports a study. However, TRT does not improve erectile function.

TRT boosts sexual function, eases symptoms in men with hypogonadism

22 Feb 2024

Immunogenicity does not affect pharmacokinetics, efficacy of tirzepatide

22 Feb 2024 bởi

Treatment-emergent (TE) antidrug antibodies (ADA) do not show any influence on the pharmacokinetics or efficacy of tirzepatide (TZP), as shown in a study. Most of the hypersensitivity or injection site reactions in patients with TE ADA are either mild or moderate in severity.

Immunogenicity does not affect pharmacokinetics, efficacy of tirzepatide