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Reducing alcohol consumption helps lower the risk of future adverse cardiovascular events, especially angina and ischaemic stroke, among people who drink heavily, according to a study.

Drinking less alcohol confers cardiovascular benefits among heavy drinkers

Real-world COPD treatment practices in SG lag behind updated guidelines

Many patients with chronic obstructive pulmonary disease (COPD) in Singapore could benefit from treatment escalation under the latest Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines, as reported by a group of researchers.

Real-world COPD treatment practices in SG lag behind updated guidelines

02 Apr 2024

Vitamin B12 supplementation improves human milk status in mothers

Maternal supplementation with vitamin B12 provides benefits on both short- and long-term human milk (HM) status, as shown in a study.

Vitamin B12 supplementation improves human milk status in mothers

Novel neutralizing mAb offers potential treatment for cerebral ischaemic injury

Researchers from a joint team at the University of Hong Kong (HKU) and Chinese Academy of Sciences have developed a novel neutralizing monoclonal antibody (mAb; 6H2) that targets circulating adipocyte fatty acid–binding protein (A-FABP), offering potential in alleviating cerebral ischaemic injury.

Novel neutralizing mAb offers potential treatment for cerebral ischaemic injury

Renal denervation affords durable BP control

Renal denervation yields substantial reductions in ambulatory systolic blood pressure for up to 36 years in randomized controlled trials and up to 10 years in observational cohort studies without compromising renal function, according to the results of a systematic review and meta-analysis.

Renal denervation affords durable BP control

Prenatal topiramate not associated with autism in offspring

Prenatal exposure to topiramate does not increase the risk of autism in offspring, a US nationwide cohort study has shown.

Prenatal topiramate not associated with autism in offspring

02 Apr 2024

Pembrolizumab plus chemo ups survival in advanced endometrial cancer across MMR subgroups

Adding pembrolizumab to standard chemotherapy resulted in a favourable overall survival (OS) benefit in patients with advanced or recurrent endometrial cancer compared with chemotherapy alone, regardless of mismatch repair (MMR) status, according to a key prespecified secondary analysis of the NRG-GY018 trial presented at the SGO 2024.

Pembrolizumab plus chemo ups survival in advanced endometrial cancer across MMR subgroups

Edoxaban matches apixaban for stroke prevention in very elderly population

Very elderly patients with nonvalvular atrial fibrillation fare well with either edoxaban or apixaban in terms of stroke prevention, although those on edoxaban may have higher bleeding risk, according to a study.

Edoxaban matches apixaban for stroke prevention in very elderly population

Plasma caffeine concentrations tied to reduced IBD risk

A recent study has found that genetically predicted higher plasma caffeine concentrations can lower the risk of inflammatory bowel disease (IBD), including its subtypes.

Plasma caffeine concentrations tied to reduced IBD risk