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Isoniazid preventive therapy is safe to use in pregnant women with HIV, especially those with a CD4 count <350 cells/μl, conferring protection against incident tuberculosis (TB) without deleterious maternal and foetal consequences, a study has shown.

Isoniazid preventive therapy safe, effective against TB in pregnant women with HIV

Tenofovir on par with entecavir for HCC prevention in CHB patients

No significant difference is seen between entecavir and tenofovir disoproxil fumarate (TDF) in terms of their effectiveness for preventing hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB), according to a recent study.

Tenofovir on par with entecavir for HCC prevention in CHB patients

Tenapanor proven safe, effective in treatment of IBS with constipation

Treatment with tenapanor 50 mg twice daily (bid) results in improvement of constipation-predominant irritable bowel syndrome (IBS-C) symptoms and is generally well tolerated, a phase III study has shown.

Tenapanor proven safe, effective in treatment of IBS with constipation

Aflibercept plus anti-PDGFRβ combo does not improve vision outcomes in nAMD

The combination of intravitreal aflibercept and antiplatelet-derived growth factor receptor β (anti-PDGFRβ) falls short of improving best-corrected visual acuity (BCVA) in patients with treatment-naïve neovascular age-related macular degeneration (nAMD), as compared with intravitreal aflibercept injection (IAI) monotherapy, a phase II study has shown.

Aflibercept plus anti-PDGFRβ combo does not improve vision outcomes in nAMD

Donor selection for FMT key to sustained UC remission

14 Feb 2020 bởi

Donor selection for faecal microbiota transplant (FMT) can make a difference to maintenance of long-term remission in patients with ulcerative colitis (UC), reveals a study presented at the 2020 Crohn's & Colitis Congress (CCC).

Donor selection for FMT key to sustained UC remission

Comparable CVD, mortality rates with human or analogue insulin in T2D

14 Feb 2020 bởi

A US-based retrospective cohort study has shown no difference in the rates of mortality and cardiovascular disease (CVD) with initiation and continuous use of either analogue or human insulin in insulin-naïve adults with type 2 diabetes (T2D).

Comparable CVD, mortality rates with human or analogue insulin in T2D

Fosfomycin trometamol on par with other antibiotics for treatment of acute uncomplicated cystitis

The clinical and microbiological effectiveness of a single dose of oral fosfomycin trometamol is comparable to that of comparator antibiotics, as is safety, in women with confirmed or suspected acute uncomplicated cystitis, a recent study has shown. Use of fosfomycin trometamol is also associated with high patient compliance.

Fosfomycin trometamol on par with other antibiotics for treatment of acute uncomplicated cystitis

Apremilast may be beneficial to patients with active ulcerative colitis

The use of apremilast in the treatment of patients with active ulcerative colitis (UC) falls short of inducing clinical remission, although it leads to marked improvements in clinical and endoscopic features and markers of inflammation, according to the results of a phase II trial.

Apremilast may be beneficial to patients with active ulcerative colitis

Sequential more cost-effective than standard triple therapy for H. pylori infection

A 10-day or 14-day sequential therapy strategy is more cost-effective than a conventional triple therapy in the management of patients with Helicobacter pylori infection, in addition to being more effective in terms of eradication of infection, as reported in a study from Egypt.

Sequential more cost-effective than standard triple therapy for H. pylori infection