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The use of cabergoline as bridge treatment in Cushing’s disease patients who have undergone radiotherapy does not appear to affect initial remission but is associated with increased recurrence following initial remission, a study reports.

Peri-radiotherapy use of cabergoline may promote recurrence in Cushing’s disease

Tofacitinib trumps vedolizumab for short-term efficacy in ulcerative colitis

Short-term efficacy appears to be higher with tofacitinib (TOF) than with vedolizumab (VDZ) in the treatment of patients with ulcerative colitis (UC), regardless of disease severity and previous biologics use, a recent study has shown.

Tofacitinib trumps vedolizumab for short-term efficacy in ulcerative colitis

Vitamin C-thiamine-hydrocortisone combo yields no improvement in septic shock

29 Jan 2020 bởi

A combination of intravenous vitamin C, hydrocortisone, and thiamine did not reduce mortality or dependence on vasopressors in patients with septic shock* in the intensive care unit (ICU), according to results of the VITAMINS** trial presented at the recent Critical Care Reviews meeting (CCR20).

Vitamin C-thiamine-hydrocortisone combo yields no improvement in septic shock

Steroids therapy effective in immune checkpoint inhibitor-related colitis

Patients with immune checkpoint inhibitor-related colitis (irAE-colitis) may benefit from steroid therapy, suggests a study, adding however that some cases of early relapse has occurred.

Steroids therapy effective in immune checkpoint inhibitor-related colitis

Vedolizumab use in pregnancy conveys low risk of adverse outcomes

The risk of adverse pregnancy outcomes appears to be low in women treated with vedolizumab for inflammatory bowel disease, a study has found.

Vedolizumab use in pregnancy conveys low risk of adverse outcomes

Irbesartan tied to lower aortic root dilatation rates in patients with Marfan syndrome

29 Jan 2020 bởi

Routine use of the long-acting angiotensin receptor blocker (ARB) irbesartan was associated with a reduction in the rate of aortic root dilatation – which is associated with dissection and rupture – in children and young adults with Marfan syndrome compared with placebo over a 5-year observation period, according to the AIMS* study.

Irbesartan tied to lower aortic root dilatation rates in patients with Marfan syndrome

Doing without valproate in women with epilepsy results in clinical worsening

29 Jan 2020 bởi

In the treatment of idiopathic generalized epilepsy, switching from valproate to other antiepileptic drugs due to potential childbearing issues may prove detrimental, heightening the risk of poor seizure control, as shown in a recent study.

Doing without valproate in women with epilepsy results in clinical worsening

Another role for SGLT2is: Gout prevention?

28 Jan 2020 bởi

Individuals with type 2 diabetes (T2D) who are prescribed an SGLT2* inhibitor may have a reduced risk for developing gout compared with those who are prescribed a GLP-1** receptor agonist, according to a study from the US.

Another role for SGLT2is: Gout prevention?

Drug treatment in out-of-hospital cardiac arrest: Does vascular access route matter?

28 Jan 2020 bởi

Lidocaine and amiodarone yield similar gains in survival when used to treat shock-refractory out-of-hospital cardiac arrest (OHCA) relative to placebo, along with a more favourable neurological outcome at hospital discharge when administered intravenously, as shown in a recent study. Conversely, these beneficial effects may not be observed when the drugs are given via the intraosseous route.

Drug treatment in out-of-hospital cardiac arrest: Does vascular access route matter?

Combination sequential therapy improves survival in SSc-related pulmonary arterial hypertension

Combination sequential therapy appears to be a beneficial alternative to monotherapy, leading to improved survival in patients with systemic sclerosis (SSc)-related pulmonary arterial hypertension (PAH), a study has shown.

Combination sequential therapy improves survival in SSc-related pulmonary arterial hypertension