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A triplet regimen combining the PARP inhibitor olaparib with metronomic cyclophosphamide and metformin showed favourable signals for heavily pretreated women with advanced endometrial carcinoma, the phase I/II ENDOLA study suggests.

New chemo-free triplet regimen shows promise for endometrial cancer

09 May 2022

What drives persistent distress in COVID-19 frontliners?

Frontline nurses in Singapore and Japan are at risk of prolonged psychological distress after caring for COVID-19 patients, according to a recent study. Such distress also persists in healthcare workers who have underlying medical conditions or who have dealt with an outbreak in the hospital.

What drives persistent distress in COVID-19 frontliners?

09 May 2022

Bariatric surgery bests medical treatment in Asians with diabetes, class I obesity

Roux-en-Y gastric bypass (RYGB) appears to produce more favourable improvements in terms of glycaemic control and weight loss when compared with medical treatment in Asian patients with type 2 diabetes mellitus (T2DM) and class I obesity, according to a study.

Bariatric surgery bests medical treatment in Asians with diabetes, class I obesity

$Sacubitril/valsartan useful in heart failure with reduced ejection fraction$

Sacubitril/valsartan useful in heart failure with reduced ejection fraction

Treatment with sacubitril/valsartan appears to improve right ventricular performance and pulmonary hypertension among patients with heart failure with reduced ejection fraction (HFrEF), independent of the reverse remodelling of the left ventricle, as reported in a study.

Sacubitril/valsartan useful in heart failure with reduced ejection fraction

Toripalimab plus chemo improves survival in NSCLC

The addition of toripalimab to first-line chemotherapy led to significantly improved progression-free survival (PFS) and overall survival (OS) in patients with advanced non-small cell lung cancer (NSCLC) without EGFR/ALK mutations, according to the updated results of the CHOICE-01* trial presented at the ASCO Plenary 2022.

Toripalimab plus chemo improves survival in NSCLC

AChEIs and memantine cost-effective, offer improvements in AD

A systematic review and meta-analysis of Alzheimer’s disease (AD) therapies’ cost-effectiveness carried out by researchers from the Chinese University of Hong Kong (CUHK) identifies acetylcholinesterase inhibitors (AChEIs) and memantine as cost-effective and offering improvements in dementia-related symptoms.

AChEIs and memantine cost-effective, offer improvements in AD

09 May 2022

Vulvovaginal candidiasis often misdiagnosed, overtreated

Diagnostic testing is rarely applied in patients with vulvovaginal candidiasis, leading to misdiagnoses and overprescribing of antifungal medications and unnecessary use of antibacterial agents, reports a recent study.

Vulvovaginal candidiasis often misdiagnosed, overtreated

11 causal risk factors for CVD that can be modified

A systematic Mendelian randomization study has identified several modifiable cardiovascular disease (CVD) causal risk factors, including hypertension, smoking, and high body mass index.

11 causal risk factors for CVD that can be modified

Excessive glucocorticoid exposure may interfere with neuronal maturation in utero

Excessive exposure to glucocorticoids appears to impede neuronal maturation in utero, which can result in greater disease susceptibility through neurodevelopmental processes at the interface of genetic susceptibility and environmental exposure, suggests a study.

Excessive glucocorticoid exposure may interfere with neuronal maturation in utero

ADHD more likely in preschoolers with lazy eye; impaired fine motor skill a mediator