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Cardiorenal benefit with investigational GLP-1 RA independent of concurrent SGLT2 inhibitor
The glucagon-like peptide-1 receptor agonist (GLP-1 RA) efpeglenatide affords cardiovascular and renal protection that is not explained by concurrent use of a sodium-glucose co-transporter-2 (SGLT2) inhibitor in patients with type 2 diabetes (T2D), according to an exploratory analysis of AMPLITUDE-O.
Cardiorenal benefit with investigational GLP-1 RA independent of concurrent SGLT2 inhibitor
30 Nov 2021
Remnant cholesterol tied to CVD death in patients with T2D, CKD, diabetic nephropathy
Remnant cholesterol (C) appears predictive of mortality due to cardiovascular disease (CVD) among patients with type 2 diabetes (T2D), chronic kidney disease (CKD) stage 3 to 5, and incident diabetic nephropathy (DN), suggests a study.
Remnant cholesterol tied to CVD death in patients with T2D, CKD, diabetic nephropathy
29 Nov 2021
Insulin secretion predicts response to therapy in new-onset diabetes
The increase in C-peptide (C-Pep) above fasting following glucose load is associated with response to antihyperglycaemic therapy in patients with new-onset type 2 diabetes mellitus (T2DM), according to a study. The plasma C-Pep concentration ratio (C-Pep120/C-Pep0) may be used for the individualization of such therapy in this population.
Insulin secretion predicts response to therapy in new-onset diabetes
29 Nov 2021
Which amino acids are associated with cardiovascular events?
A recent study has recognized alanine and glutamine as new amino acids that appear to increase the risk of coronary artery disease (CAD) and reduce the hazard of ischaemic stroke, respectively.
Which amino acids are associated with cardiovascular events?
28 Nov 2021
Homocysteine tied to spinal osteoarthritis prevalence in postmenopausal women
Circulating homocysteine and C677T variant in methylenetetrahydrofolate reductase (MTHFR) appear to influence the prevalence rate and ensuing progression of spinal osteoarthritis (OA), respectively, in postmenopausal women, a study has shown.
Homocysteine tied to spinal osteoarthritis prevalence in postmenopausal women
28 Nov 2021
High acute-to-chronic glycaemic ratio tied to worse prognosis in T2D patients with COVID-19
Type 2 diabetes (T2D) patients with COVID-19 who have elevated acute-to-chronic (A/C) glycaemic ratio are at increased risk of adverse outcomes, including in-hospital mortality, intensive care unit (ICU) admission, and mechanical ventilation, a study has found.