Cushing's Syndrome Disease Summary

Last updated: 11 November 2024

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Overview

Cushing’s syndrome is a condition caused by prolonged exposure to excess cortisol (glucocorticoid hormone).
Signs and symptoms include progressive obesity, facial plethora, wasting in the extremities, thin skin, acne, easy bruising, violaceous stria width >1 cm, hyperpigmentation, hirsutism (in women), proximal muscle weakness, impotency in men, changes in libido, menstrual disorders, depression or lethargy, central serous chorioretinopathy, and recurrent fungal and/or bacterial infection. 
Laboratory tests and radiological findings confirm diagnosis and determine the actual cause of Cushing's syndrome.
Provide adequate glucocorticoid replacement following surgery until hypothalamic-pituitary-adrenal (HPA) axis has recovered.

For further information regarding the management of Cushing's Syndrome, please refer to Disease Algorithm for the Treatment Guideline.