Alzheimer's Disease & Dementia Differential Diagnosis

Last updated: 10 June 2024

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Differential Diagnosis

The following diseases should be considered: Amnestic disorder, age-related memory impairment, delirium, major depressive disorder, schizophrenia, mild cognitive impairment (MCI), structural brain pathologies (eg tumors, vascular malformations, hydrocephalus), obstructive sleep apnea, drug intoxication, central nervous system (CNS) infections.

Mild Cognitive Impairment (MCI)

MCI is a condition demonstrating focal or multifocal (one or more) cognitive domain impairment not normal for age with or without minimal instrumental ADL impairment. It is an intermediate state between normal aging and dementia. MCI can be a primary manifestation of AD, and be secondary in other forms of dementia, neurologic disease processes, psychiatric disorders or even systemic disease. Amnestic MCI (aMCI) is a syndrome characterized by prominent memory dysfunction. Nonamnestic MCI presents as prominent impairment in other cognitive features (eg executive, language, visuo-spatial). It must be noted that patients with MCI have a greater risk of dementia. As such, these patients are encouraged to return for re-evaluation in 6-12 months.