Premature Ejaculation Disease Summary

Premature ejaculation is a male sexual dysfunction characterized by short, easily stimulated ejaculation that occurs always or nearly always before or within about 1 minute of vaginal penetration or other relevant sexual stimulation or a clinically significant and bothersome reduction in latency time, often to about 3 minutes or less.
It is involuntarily controlled and causes negative personal consequences like distress, frustration and avoidance of sexual intimacy.
Basis of treatment is lifelong premature ejaculation, but all medical treatments (except for Dapoxetine and Lidocaine-Prilocaine spray) are off-label indications. Chronic antidepressants including selective serotonin reuptake inhibitors (SSRIs) and Clomipramine and on-demand topical anesthetic agents have consistently shown efficacy in premature ejaculation.

For further information regarding the management of Premature Ejaculation, please refer to Disease Algorithm for the Treatment Guideline.