Lymphoma leads to poorer outcomes after percutaneous coronary intervention

While uncommon in patients undergoing percutaneous coronary intervention (PCI), lymphoma appears to worsen prognosis after the procedure, a new study has shown.

Accessing the National Inpatient Sample, researchers retrieved the information of 7,119,539 patients who underwent PCI between the years 2004 and 2014. The main outcomes of interest were in-hospital mortality and procedure-associated complications, including vascular and cardiac problems, bleeding, and postprocedural stroke or transient ischaemic attacks.

Of the participants, 3,516 were diagnosed with Hodgkin’s lymphoma (median age at admission, 55 years; 68.4 percent male) and 14,536 with non-Hodgkin’s lymphoma (median age at admission, 71 years; 66.9 percent male). The overall prevalence rate of lymphoma over the 10-year observation period was 0.25 percent.

Overall (10.1 percent and 13.5 percent vs 8.1 percent; p-both<0.001) and bleeding (5.0 percent and 7.7 percent vs 3.0 percent; p-both<0.001) complications both occurred significantly more frequently in patients with Hodgkin’s and non-Hodgkin’s lymphoma as compared to their counterparts without the diagnosis, respectively.

The same was true for vascular and cardiac complications, postprocedural stroke, and in-hospital mortality.

Multivariable regression analysis further confirmed these findings. Bleeding (odds ratio [OR], 1.12, 95 percent CI, 1.06–1.19) and vascular complications (OR, 1.11, 1.05–1.18) and postprocedural stroke (OR, 1.75, 1.61–1.90) were all significantly more likely to develop in those with lymphoma. The risk of in-hospital death was likewise elevated in these patients (OR, 1.39, 1.25–1.54).