News &amp; Updates

Treatment with lovastatin appears to have neither anti-inflammatory nor clinical effects on mild rheumatoid arthritis (RA) disease activity, although it produces a modest reduction in C-reactive protein (CRP) in patients not using biologics, according to the results of a phase II study.

Lovastatin demonstrates anti-inflammatory effect in selected mild RA patients

Podcast: Assoc Prof Yeo Khung Keong talks about the hopes and promises of AI in cardiology

Podcast: Assoc Prof Yeo Khung Keong talks about the hopes and promises of AI in cardiology

Tocilizumab induces remission in polymyalgia rheumatica even without glucocorticoids

17 Nov 2019

Monotherapy with tocilizumab (TCZ) shows good tolerability profile and results in remission in most patients with polymyalgia rheumatica (PMR) despite the absence of glucocorticoids, according to the 2-year results of a single-centre, open‐label pilot study.

Tocilizumab induces remission in polymyalgia rheumatica even without glucocorticoids

17 Nov 2019

Exciting times in renal space: ARNi combo bests valsartan in HFpEF

17 Nov 2019 by

The combination of sacubitril and valsartan results in fewer renal events and slows kidney disease progression vs valsartan alone in patients with heart failure (HF) and preserved ejection fraction (HFpEF) in the post-hoc analysis of 5,000 patients from the PARAGON-HF trial.

Exciting times in renal space: ARNi combo bests valsartan in HFpEF

17 Nov 2019

$Selinexor–dexamethasone combo shows activity against refractory multiple myeloma$

Selinexor–dexamethasone combo shows activity against refractory multiple myeloma

The combination of oral selinexor plus dexamethasone appears to induce response in patients with triple-class refractory myeloma, according to data from the second part of the phase II STORM* study.

Selinexor–dexamethasone combo shows activity against refractory multiple myeloma

Tafulprost safe, effective for managing IOP in glaucoma

Tafulprost is a safe and effective treatment for lowering intraocular pressure (IOP) in glaucoma patients, a recent Philippine study has shown.

Tafulprost safe, effective for managing IOP in glaucoma

COOL-AF data point to unmet need for stroke prevention in NVAF patients in Thailand

15 Nov 2019 by

Many patients with nonvalvular atrial fibrillation (NVAF) in Thailand use anticoagulants, but the uptake of nonvitamin-K oral anticoagulants remains suboptimal despite showing an upward trend, according to data from the COOL-AF registry presented at the European Society of Cardioloy (ESC) Asia Congress 2019 with APSC and AFC.

COOL-AF data point to unmet need for stroke prevention in NVAF patients in Thailand

Denosumab tied to higher rates of hyper-, hypocalcaemia in cancer patients with bone metastasis

The incidence of both hypercalcaemia and hypocalcaemia in cancer patients with bone metastasis appears to be higher with denosumab as compared to zoledronic acid, a recent study has shown. Moreover, adequate supplementation with calcium helps lower the risk of hypocalcaemia.

Denosumab tied to higher rates of hyper-, hypocalcaemia in cancer patients with bone metastasis

Lenvatinib use appears to disrupt wound healing

Lenvatinib, a vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitor for thyroid and renal malignancies, seems to play a role in wound healing complications based on temporality and biologic plausibility, suggests evidence from the US Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).

Lenvatinib use appears to disrupt wound healing

Thiazide may do more harm than good in type 2 diabetics with well-controlled BP

The use of thiazides appears to contribute to an increased risk of stroke in patients with type 2 diabetes, specifically in those receiving intensive blood pressure (BP) control, a recent study has found.

Thiazide may do more harm than good in type 2 diabetics with well-controlled BP