Heart failure prevalence in Chinese ACS patients influenced by uric acid levels

Serum uric acid appears to play some role in the prevalence of heart failure among Chinese patients with acute coronary syndrome (ACS), as reported in a study.

The analysis included 1,075 Chinese ACS patients. They completed standardized and structured questionnaires that gathered information on demographic characteristics (age, gender, body mass index [BMI], ethnicity), vascular risk factors (smoking status, drinking status, hypertension, diabetes mellitus), and routine medical conditions (creatinine, lipid profile, homocysteine, application of diuretic).

Researchers grouped serum uric acid levels into quartiles. They also applied binary logistic regression models to examine associations of serum uric acid with HF due to ACS. Finally, a subgroup analysis was performed to determine potential ethnic-specific associations.

Multivariable analysis showed that the prevalence of HF due to ACS increased in proportion to the levels of serum uric relative to the lowest quartile (quartile 2: odds ratio [OR], 0.69, 95 percent confidence interval [CI], 0.44–1.08; quartile 3: OR, 1.06, 95 percent CI, 0.67–1.67; quartile 4: OR, 2.19, 95 percent CI, 1.35–3.56; p_trend<0.001).

Subgroup analyses did not indicate any ethnic-specific differences between serum uric acid and HF due to ACS.  The highest SUA level was significantly associated with the risk of HF due to ACS in both the Han (quartile 4 vs 1: OR, 1.85, 95 percent CI, 1.02–3.37) and the Mongolians (quartile 4 vs 1: OR, 6.82, 95 percent CI, 1.90–24.50).