News &amp; Updates

Replacing saturated with unsaturated fat seems to have no significant impact on insulin sensitivity or pancreatic β-cell function, according to a study.

Does unsaturated fat substitution improve glucose homeostasis?

Is there a need to re-evaluate HbA1c cutoff in premenopausal women?

18 Oct 2023 by

In an analysis of over a million individuals in England, women aged <50 years had a markedly lower HbA1c distribution than men, suggesting that the application of the current HbA1c reference range may lead to underdiagnosis of type 2 diabetes (T2D) in premenopausal women.

Is there a need to re-evaluate HbA1c cutoff in premenopausal women?

18 Oct 2023

Original New Drug Application Approvals by US FDA (01-15 October 2023)

New drug applications approved by US FDA as of 01-15 October 2023 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (01-15 October 2023)

Bivalent mRNA vaccine confers protection against SARS-COV-2 infection in young children

18 Oct 2023 by

Bivalent COVID-19 vaccine conferred protection against SARS-COV-2 infection among children and adolescents aged 5–11 years, according to a recent study presented at IDWeek 2023.

Bivalent mRNA vaccine confers protection against SARS-COV-2 infection in young children

Perioperative antiplatelet therapy prevents adverse events in noncardiac surgery patients

A continuation strategy with antiplatelet therapy (APT) appears to reduce net adverse clinical events (NACE) and major adverse cardiovascular events (MACE) at 30 days in patients undergoing noncardiac surgery within a year after percutaneous coronary intervention (PCI), with a similar incidence of major bleeding, relative to an APT discontinuation strategy, a recent study has shown.

Perioperative antiplatelet therapy prevents adverse events in noncardiac surgery patients

Does early antihypertensive treatment prevent death in stroke patients?

Early antihypertensive treatment appears to have no significant benefits in terms of dependency or death at 90 days among patients with mild-to-moderate acute ischaemic stroke and systolic blood pressure (SBP) between 140 and <220 mm Hg, reports a study.

Does early antihypertensive treatment prevent death in stroke patients?

17 Oct 2023

EVT plugs leaks, perforations in upper GI tract

Use of endoscopic vacuum therapy (EVT), a new technique for closing upper gastrointestinal (UGI) defects, results in the closure of defects, such as anastomotic leak and perforations of the upper digestive tract, with only a few serious adverse events (AEs), a study has shown.

EVT plugs leaks, perforations in upper GI tract

ARCADIA trials: A win for nemolizumab in atopic dermatitis

In the phase III ARCADIA 1 and 2 trials, the investigational, first-in-class interleukin-31-Rα antagonist nemolizumab delivered early, rapid, and sustained improvements in the core signs and symptoms of atopic dermatitis (AD) in patients with moderate-to-severe disease.

ARCADIA trials: A win for nemolizumab in atopic dermatitis

17 Oct 2023

Prednisolone ≥5 mg/day doubles risk of MACE in RA patients

In patients with rheumatoid arthritis (RA), use of systemic glucocorticoids (GC) is associated with a time- and dose-dependent increase in risk of major adverse cardiovascular events (MACE), a population-based real-world study has shown. On long-term follow-up, a prednisolone dose of ≥5 mg/day is associated with a doubled risk of MACE vs no GC use, and no safe duration of use is found for this daily GC dose.

Prednisolone ≥5 mg/day doubles risk of MACE in RA patients

17 Oct 2023

Chikungunya vaccine induces robust immune response in adolescents, adults

The use of chikungunya virus-like particle vaccine (CHIKV VLP) results in significantly higher seroresponse rate* and superior immunogenicity in adolescents and adults compared with placebo, according to two pivotal phase III trials presented at IDWeek 2023.

Chikungunya vaccine induces robust immune response in adolescents, adults