News & Updates

PARG inhibition slows HCC progression, boosts efficacy of immune checkpoint therapy
PARG inhibition slows HCC progression, boosts efficacy of immune checkpoint therapy
05 Jul 2022

In hepatocellular carcinoma (HCC), poly(ADP-ribose) glycohydrolase (PARG) may serve as an oncogene by modulating PARG/DDB1/c-Myc signaling and be used as a biomarker to identify HCC patients who may derive benefit from anti-PD-1 treatment, suggests a study.

PARG inhibition slows HCC progression, boosts efficacy of immune checkpoint therapy
05 Jul 2022
Concurrent DOAC, tamoxifen use poses no elevated bleeding risk
Concurrent DOAC, tamoxifen use poses no elevated bleeding risk
05 Jul 2022

In breast cancer patients receiving direct oral anticoagulants (DOACs), tamoxifen is safe to use and does not increase the risk of haemorrhage as compared with concurrent use of an aromatase inhibitor (AI), a study has found.

Concurrent DOAC, tamoxifen use poses no elevated bleeding risk
05 Jul 2022
TNFi use carries only modest increase in psoriasis risk
TNFi use carries only modest increase in psoriasis risk
04 Jul 2022 byJairia Dela Cruz

The use of tumour necrosis factor-α inhibitor (TNFi) for inflammatory bowel disease (IBD) or rheumatoid arthritis (RA) raises the risk of developing psoriasis by twofold as compared with conventional therapy, although the absolute risk remains modest, as reported in a study.

TNFi use carries only modest increase in psoriasis risk
04 Jul 2022
Statins reduce death, mechanical ventilation use in hospitalized COVID-19 patients
Statins reduce death, mechanical ventilation use in hospitalized COVID-19 patients
04 Jul 2022 byStephen Padilla

Hospitalized patients with COVID-19 who are treated with statins are less likely to undergo invasive mechanical ventilation or die, according to the results of a multicentre study in the US.

Statins reduce death, mechanical ventilation use in hospitalized COVID-19 patients
04 Jul 2022