News & Updates

High-dose zinc intake tied to less feeding intolerance in VLBW infants

High-dose zinc supplementation was significantly associated with decreased feeding intolerance in very low birth weight (VLBW) preterm infants, according to a study presented at ESPGHAN 2022.

Inotuzumab ozogamicin safe, effective in relapsed, refractory paediatric ALL

Inotuzumab ozogamicin is well tolerated and demonstrates clinical activity in children with relapsed or refractory acute lymphoblastic leukaemia (ALL), according to the results of a phase II trial.

Novel targeted therapy shows better response than chemo in BRAF V600-mutant paediatric LGG

The combination of two targeted therapies, dabrafenib and trametinib, significantly improves the overall response rate (ORR) in paediatric patients with low-grade glioma (LGG) with BRAF V600 mutations compared with the combination of standard chemotherapy drugs, according to a study presented at ASCO 2022.

Portable bladder ultrasound device provides accurate measurements in toddlers

The children’s module of the Bladder Scanner (BS), a portable ultrasound device used to measure bladder volume, shows acceptable accuracy in children 4 years of age and above, according to a recent study. However, device performance appears unreliable in younger children.

Nitric oxide during heart surgery of no benefit in young kids

The delivery of nitric oxide into the cardiopulmonary bypass in young children undergoing surgery for congenital heart disease does not significantly reduce the number of ventilator-free days, as shown in a study.

Routine cerebral magnetic resonance imaging catches low-grade pathologies in preemies

The routine implementation of cerebral magnetic resonance imaging (cMRI) commonly detects low-grade abnormalities in extremely premature infants, such as low-grade intraventricular haemorrhage (IVH), white matter disease (WMD), and cerebellar injury (CBI), a new study has found.

COVID-19 shots for tots OK’d

The 2-year wait is over.

Management of multidrug-resistant organisms in paediatric patients: Role of newer antimicrobial agents

The management of multidrug-resistant (MDR) infections in children is complex, with limited studies and a relative lack of approved new antibiotics with paediatric indications.

At a recent Meet-the-Expert session, Dr Louis Grandjean, Consultant in Paediatric Infectious Diseases at Great Ormond Street Hospital and Associate Professor at University College, London, UK, addressed the growing threat of MDR infections in children and discussed treatment strategies and options for management. He focused on ceftazidime-avibactam (CAZ-AVI, Zavicefta^®), whose approval in Singapore was recently expanded to include paediatric patients aged 3 months and older.

Adj Asst Prof Natalie Tan, Senior Consultant at KK Women’s and Children’s Hospital, Singapore, chaired this webinar, which was organized by Pfizer under the auspices of the Singapore Paediatric Society and KK Women’s and Children’s Hospital.