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Bulevirtide boasts high barrier to resistance for chronic hepatitis delta
A recent study has found no amino acid substitutions associated with reduced sensitivity to bulevirtide (BLV) monotherapy, a hepatitis D/B virus (HDV/HBV) entry inhibitor, at baseline or week 24 in patients with virologic breakthrough after BLV treatment.
Bulevirtide boasts high barrier to resistance for chronic hepatitis delta
13 Sep 2023Which factors predict sustained RA remission with MTX or ETN monotherapy?
Following the switch from combination therapy to monotherapy, rheumatoid arthritis (RA) patients with overall lower disease activity (LDA) have higher odds of achieving and remaining in Simplified Disease Activity Index (SDAI) remission/LDA, suggests a study.
Which factors predict sustained RA remission with MTX or ETN monotherapy?
12 Sep 2023VELO supports liquid biopsy-guided anti-EGFR rechallenge therapy in mCRC
In the phase II VELO trial, third-line (3L) treatment with the anti-EGFR* monoclonal antibody (mAb) panitumumab and standard of care (SoC) improved progression-free survival (PFS) in patients with refractory RAS wild-type metastatic colorectal cancer (WT mCRC).
VELO supports liquid biopsy-guided anti-EGFR rechallenge therapy in mCRC
12 Sep 2023Triple G agonist shows therapeutic potential in obesity
Treatment with retatrutide, the novel agonist of the glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1, and glucagon receptors, leads to marked reductions in body weight in individuals with obesity, as shown in the results of a phase II trial.
Triple G agonist shows therapeutic potential in obesity
11 Sep 2023HEART-FID confirms IV iron safety for HF but falls short in efficacy
The HEART-FID trial narrowly missed its primary endpoint, showing modest improvement in all-cause mortality, heart failure hospitalizations (hHF), and exercise function with ferric carboxymaltose (FCM) in HFrEF* patients with iron deficiency (ID).