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Complicated urinary tract infection (UTI) is UTI associated with factors that increases colonization and decreases therapy efficacy.
Factors may include anatomical or functional abnormalities of the genitourinary tract, presence of an underlying disease that interferes with host defense mechanisms or the patient being immunocompromised, and being infected by a multi-drug resistant bacteria.
Principles of therapy includes effective antimicrobial antimicrobial therapy, optimal management of the underlying abnormalities or other diseases, adequate life-supporting measures.