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PEMBROLIZUMAB MANG LẠI KỲ VỌNG SỐNG MỚI TRONG ĐIỀU TRỊ BƯỚC 1 UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN TIẾN XA – KHÔNG CÓ ĐỘT BIẾN GEN EGFR VÀ ALK

05 Oct 2021

Điều trị bước 1 ung thư phổi không tế bào nhỏ (UTPKTBN) giai đoạn tiến xa cả tế bào vảy và không vảy, không có gen đột biến với pembrolizumab đơn trị/phối hợp với hóa trị (HT) bộ đôi mang lợi ích sống còn toàn bộ (OS) chưa từng có tiền lệ và nhất quán so với hóa trị, được minh chứng qua các nghiên cứu pha III: Nghiên cứu KEYNOTE-189; KEYNOTE-407 và KEYNOTE-024.
NCCN khuyến cáo pembrolizumab là một lựa chọn ưu tiên đầu tay trong điều trị bước 1 UTPKTBN giai đoạn tiến xa trên không có gen đột biến (mức khuyến cáo loại 1).

PEMBROLIZUMAB MANG LẠI KỲ VỌNG SỐNG MỚI TRONG ĐIỀU TRỊ BƯỚC 1 UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN TIẾN XA – KHÔNG CÓ ĐỘT BIẾN GEN EGFR VÀ ALK

05 Oct 2021

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

05 Oct 2021

Treatment with leuprolide acetate every 6 months does not elicit significant changes in health-related quality of life (HRQOL) among prostate cancer (PC) patients despite substantial deterioration of body and role functions, a recent study has found.

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

05 Oct 2021

COVID-19 in childhood cancer patients: What are the risk factors?

04 Oct 2021 bởi

A large international database study has shown that children and adolescents with cancer have an elevated risk of severe or critical disease if infected with COVID-19. Furthermore, about half the patients receiving cancer therapy experienced modifications to their treatment regimens.

COVID-19 in childhood cancer patients: What are the risk factors?

04 Oct 2021

Original New Drug Application Approvals by US FDA (16-30 September 2021)

04 Oct 2021

New drug applications approved by US FDA as of 16 -30 September 2021 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Original New Drug Application Approvals by US FDA (16-30 September 2021)

04 Oct 2021

Dose escalation intolerance disrupts maintenance therapy of children with ALL

03 Oct 2021

Only a few children with acute lymphoblastic leukaemia (ALL) treated with mercaptopurine (6MP) and methotrexate (MTX) complete their maintenance therapy without interruptions at the current dose escalation schedules outlined by the Children’s Oncology Group protocols, a study has shown.

Dose escalation intolerance disrupts maintenance therapy of children with ALL

03 Oct 2021

Drug interactions in breast cancer therapy may harm patients

02 Oct 2021

Several drug-drug interactions (DDIs) found in breast cancer treatment may lead to adverse consequences on patient health and therapeutic outcomes, suggests a study.

Drug interactions in breast cancer therapy may harm patients

02 Oct 2021

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

02 Oct 2021

Tyrosine kinase inhibitors (TKIs) are a safe and effective first-line treatment for metastatic renal cell cancer (mRCC), confirms a Turkey study. In addition, no significant difference has been observed among three TKI agents (sunitinib, pazopanib, and sorafenib) in terms of treatment duration, overall response rate (ORR), progression-free survival (PFS), and overall survival (OS).

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

02 Oct 2021

HPV status affects survival in penile intraepithelial neoplasia patients

02 Oct 2021

In patients with penile intraepithelial neoplasia (PeIN), testing positive for p16 overexpression, as a surrogate marker for high-risk human papillomavirus (HPV), correlates with longer disease-free survival (DFS), a recent study has found. Moreover, combination treatment with immunotherapy seems to boost response regardless of p16 status.

HPV status affects survival in penile intraepithelial neoplasia patients

02 Oct 2021

Muscle wasting shortens postsurgery survival in older CRC patients

30 Sep 2021

Muscle wasting is a risk factor for death in older patients undergoing colorectal cancer (CRC) surgery, a recent study has found.

Muscle wasting shortens postsurgery survival in older CRC patients

30 Sep 2021

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma

30 Sep 2021

Neoadjuvant treatment with vismodegib achieves mixed clinical and histological response in periocular basal cell carcinoma (BCC) but limits the need for extensive surgery, a recent study has found. Final surgical excision improves outcomes, leading to clear margins and low recurrence rates.

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma

30 Sep 2021

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PEMBROLIZUMAB MANG LẠI KỲ VỌNG SỐNG MỚI TRONG ĐIỀU TRỊ BƯỚC 1 UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN TIẾN XA – KHÔNG CÓ ĐỘT BIẾN GEN EGFR VÀ ALK

PEMBROLIZUMAB MANG LẠI KỲ VỌNG SỐNG MỚI TRONG ĐIỀU TRỊ BƯỚC 1 UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ GIAI ĐOẠN TIẾN XA – KHÔNG CÓ ĐỘT BIẾN GEN EGFR VÀ ALK

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

Leuprolide acetate maintains QOL scores in prostate cancer patients despite worsening condition

COVID-19 in childhood cancer patients: What are the risk factors?

COVID-19 in childhood cancer patients: What are the risk factors?

Original New Drug Application Approvals by US FDA (16-30 September 2021)

Original New Drug Application Approvals by US FDA (16-30 September 2021)

Dose escalation intolerance disrupts maintenance therapy of children with ALL

Dose escalation intolerance disrupts maintenance therapy of children with ALL

Drug interactions in breast cancer therapy may harm patients

Drug interactions in breast cancer therapy may harm patients

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

TKIs safe, effective as first-line therapy in cytokine-intolerant metastatic renal cell cancer

HPV status affects survival in penile intraepithelial neoplasia patients

HPV status affects survival in penile intraepithelial neoplasia patients

Muscle wasting shortens postsurgery survival in older CRC patients

Muscle wasting shortens postsurgery survival in older CRC patients

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma

Neoadjuvant vismodegib reduces need for surgery in periocular basal cell carcinoma