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Clinical Presentation
Phases
of Dengue Infection
Febrile Phase
During the febrile phase, the patient suddenly
develops a high-grade fever that commonly lasts for 2-7 days and is associated
with facial flushing, skin redness, generalized arthralgia, myalgia, headache,
anorexia, nausea, and vomiting. It may also be accompanied by sore throat,
injected pharynx, conjunctival injection, and mucosal or gastrointestinal
bleeding.
The likelihood of dengue infection is increased by a
positive tourniquet test and a progressive decrease in total WBC count. The
progression to the critical phase should be recognized promptly by monitoring
for warning signs and other clinical parameters.
Critical Phase
The critical phase occurs on days 3-7 of illness and
usually lasts for 1-2 days. The patient’s temperature lowers to ≤37.5-38°C and may have an
increase in capillary permeability concurrent with an increase in hematocrit
level. The patient may develop pleural effusion, ascites, shock, organ
impairment, metabolic acidosis, or disseminated intravascular coagulation which
may lead to severe hemorrhage depending on the degree of plasma leakage and the
volume of fluid therapy.
Other patients may
proceed with this phase even without defervescence. The changes in the full
blood count may be the only guide to determining the onset of plasma leakage.
Recovery Phase
The recovery phase is 2-3 days after the critical
phase has been successfully surpassed. Patients may present with respiratory
distress due to massive pleural effusion and ascites if excessive intravenous
fluids were given.